Antibiotics LC-MS/MS Quantitation - DZIF Online Course

In this course we will provide insights how quantitative analyses of small molecules for drug development and clinical applications are planned and performed. We will explain basics of liquid chromatography mass spectrometric (LC-MS) workflows and sample preparation. We will discuss application examples from quality controls and method optimization in early steps of drug development, preclinical stages and Pharmacokinetic/Pharmacodynamic (PK/PD) studies as well clinical application.

Program (October, 16th 2025):

10:00 am - Basics of liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) for quantitation of therapeutics (Dominik Schwudke)
10:45 am - How to choose your bioanalytical method for PK/PD studies? - basics and guiding case studies from in vitro to in vivo (Katharina Rox)
11:30 am - Questions and Discussion (Moderator Dominik Schwudke)
12:00 am - Lunch break
01:00 pm - Models for Small Moelcule driven Therapies (Lea Ann Dailey)
01:45 pm - Advanced animal models and biomarker analysis to better predict the efficacy of new anti-mycobacterial compounds (Christoph Hölscher)
02:30 pm - Questions and Discussion (Moderator Dominik Schwudke)
03:00 pm - Pharmacokinetics in clinical trials - from first in human to PK/PD (Julia Dreisbach)
03:45 pm - Closing discussion

Connection details will be send via email to the registered participants in time before the course.

Lecturer: Katharina Rox (HZI Braunschweig), Lea Ann Dailey (Universität Wien), Julia Dreisbach (LMU Clinic Munnich)
Christoph Hölscher, Dominik Schwudke (Research Center Borstel)

Contact us via antibiotics(at)fz-borstel.de for any inquiry.

This is an online event; no recordings will be made.